Details of the Drug

General Information of Drug (ID: DMJ8A3Z)

Drug Name
Florbetapir F-18
Synonyms Amyvid (TN)
Indication
Disease Entry ICD 11 Status REF
Diagnostic imaging N.A. Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 359.4
Logarithm of the Partition Coefficient (xlogp) 3.5
Rotatable Bond Count (rotbonds) 12
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C20H25FN2O3
IUPAC Name
4-[(E)-2-[6-[2-[2-(2-(18F)fluoranylethoxy)ethoxy]ethoxy]pyridin-3-yl]ethenyl]-N-methylaniline
Canonical SMILES
CNC1=CC=C(C=C1)/C=C/C2=CN=C(C=C2)OCCOCCOCC[18F]
InChI
InChI=1S/C20H25FN2O3/c1-22-19-7-4-17(5-8-19)2-3-18-6-9-20(23-16-18)26-15-14-25-13-12-24-11-10-21/h2-9,16,22H,10-15H2,1H3/b3-2+/i21-1
InChIKey
YNDIAUKFXKEXSV-CRYLGTRXSA-N
Cross-matching ID
PubChem CID
24822371
ChEBI ID
CHEBI:66880
CAS Number
956103-76-7
DrugBank ID
DB09149
TTD ID
D09CGE
ACDINA ID
D01081

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Amyloid beta A4 protein (APP) TTE4KHA A4_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Diagnostic imaging
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Amyloid beta A4 protein (APP) DTT APP 1.60E-02 -0.07 -0.31
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Ethanol E00023 702 Antimicrobial preservative; Penetration agent; Solvent
Sodium ascorbate E00554 23667548 Antioxidant
Sodium chloride E00077 5234 Diluent; Tonicity agent
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Florbetapir F-18 13.5-51mci/ml solution 13.5-51mci/ml Solution Intravenous
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015