General Information of Drug (ID: DMJZEMB)

Drug Name
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione
Synonyms CHEMBL205381; 3-isopropyl-4-(phenylthio)naphthalene-1,2-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 308.4
Logarithm of the Partition Coefficient (xlogp) 4.4
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C19H16O2S
IUPAC Name
4-phenylsulfanyl-3-propan-2-ylnaphthalene-1,2-dione
Canonical SMILES
CC(C)C1=C(C2=CC=CC=C2C(=O)C1=O)SC3=CC=CC=C3
InChI
InChI=1S/C19H16O2S/c1-12(2)16-18(21)17(20)14-10-6-7-11-15(14)19(16)22-13-8-4-3-5-9-13/h3-12H,1-2H3
InChIKey
VHVWQYNOEGPBOE-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
44409669
TTD ID
D08GWQ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
M-phase inducer phosphatase 1 (MPIP1) TTLZS4Q MPIP1_HUMAN Inhibitor [1]
M-phase inducer phosphatase 2 (MPIP2) TTR0SWN MPIP2_HUMAN Inhibitor [1]
PTPN1 messenger RNA (PTPN1 mRNA) TTELIN2 PTN1_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PTPN1 messenger RNA (PTPN1 mRNA) DTT PTPN1 9.44E-01 7.21E-03 0.08
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.