Details of the Drug

General Information of Drug (ID: DMK4VY9)

Drug Name
DS-7300
Synonyms O-(3,5-dichlorophenyl)hydroxylamine; 99907-90-1; 3,5-Dichlorophenoxyamine; Hydroxylamine, O-(3,5-dichlorophenyl)-; SCHEMBL4210449; DTXSID00471352; MFCD09029771; ZINC21987339; AKOS006290319; AK141702
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
Drug Type
Antibody drug conjugate
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 178.01
Logarithm of the Partition Coefficient (xlogp) 3.1
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C6H5Cl2NO
IUPAC Name
O-(3,5-dichlorophenyl)hydroxylamine
Canonical SMILES
C1=C(C=C(C=C1Cl)Cl)ON
InChI
InChI=1S/C6H5Cl2NO/c7-4-1-5(8)3-6(2-4)10-9/h1-3H,9H2
InChIKey
PCSYDOORDVYWPI-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11736040
TTD ID
DT8R1L

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
B7 homolog 3 (CD276) TT6CQUM CD276_HUMAN Inhibitor [2]
DNA topoisomerase I (TOP1) TTGTQHC TOP1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
B7 homolog 3 (CD276) DTT CD276 3.92E-01 -0.04 -0.81
B7 homolog 3 (CD276) DTT CD276 7.33E-02 -0.53 -1.33
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT04145622) Study of DS-7300a in Participants With Advanced Solid Malignant Tumors. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Daiichi Sankyo.