Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption: The systemic absorption of drug is up to 60% following intraperitoneal administration []
  Clearance: The clearance of drug is 0.058 L/h/kg []
  Elimination: About 75-80% of an administered dose of vancomycin is excreted in urine by glomerular filtration [1]
  Half-life: The concentration or amount of drug in body reduced by one-half in 6 hours []
  Metabolism: The drug is metabolized via the liver [1]
  Vd: The volume of distribution (Vd) of drug is 0.4-1 L/kg [2]

References

• [1] Hotta K, Ueyama J, Tatsumi Y, Tsukiyama I, Sugiura Y, Saito H, Matsuura K, Hasegawa T: Lack of Contribution of Multidrug Resistance-associated Protein and Organic Anion-transporting Polypeptide to Pharmacokinetics of Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats. Anticancer Res. 2015 Sep;35(9):4681-9.
• [2] Rybak MJ: The pharmacokinetic and pharmacodynamic properties of vancomycin. Clin Infect Dis. 2006 Jan 1;42 Suppl 1:S35-9. doi: 10.1086/491712.