Details of the Drug | DrugMAP

General Information of Drug (ID: DMKDHU2)

Drug Name

RG7716

Synonyms

RG7716; GTPL8529; RG-7716

Indication

Disease Entry	ICD 11	Status	REF
Neovascular age-related macular degeneration	9B78.3Z	Phase 3	[1]
Choroidal neovascularization	9B76	Phase 2	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C25H30ClN3O2
Canonical SMILES: CN(C)CCN1CC(C2=C1C=C(C=C2)Cl)C(=O)N3CCC4(CC3)C5=CC=CC=C5CO4
InChI: 1S/C25H30ClN3O2/c1-27(2)13-14-29-16-21(20-8-7-19(26)15-23(20)29)24(30)28-11-9-25(10-12-28)22-6-4-3-5-18(22)17-31-25/h3-8,15,21H,9-14,16-17H2,1-2H3
InChIKey: DRMVDBATNZBNEB-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 91827367
TTD ID: D07MED

Repurposed Drugs (RPD)

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References

1	ClinicalTrials.gov (NCT04777201) A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (AVONELLE-X). U.S. National Institutes of Health.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8529).