Details of the Drug

General Information of Drug (ID: DMKGTRF)

Drug Name

6-(4-fluorostyryl)-2-morpholino-4H-chromen-4-one

Synonyms

CHEMBL426654

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

351.4

Logarithm of the Partition Coefficient (xlogp)

3.9

Rotatable Bond Count (rotbonds)

3

Hydrogen Bond Donor Count (hbonddonor)

0

Hydrogen Bond Acceptor Count (hbondacc)

5

Chemical Identifiers

Formula: C21H18FNO3
IUPAC Name: 6-[(E)-2-(4-fluorophenyl)ethenyl]-2-morpholin-4-ylchromen-4-one
Canonical SMILES: C1COCCN1C2=CC(=O)C3=C(O2)C=CC(=C3)/C=C/C4=CC=C(C=C4)F
InChI: InChI=1S/C21H18FNO3/c22-17-6-3-15(4-7-17)1-2-16-5-8-20-18(13-16)19(24)14-21(26-20)23-9-11-25-12-10-23/h1-8,13-14H,9-12H2/b2-1+
InChIKey: MGIIGLFUKQWDHF-OWOJBTEDSA-N

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA-dependent protein kinase catalytic (PRKDC)	TTK3PY9	PRKDC_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46.