Details of the Drug

General Information of Drug (ID: DMKU3R1)

Drug Name

Dusquetide

Synonyms

931395-42-5; UNII-IKX7W49NLN; RIVPA; (S)-1-(L-arginyl-L-isoleucyl-L-valyl)-N-((S)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide; IKX7W49NLN; SGX94; SGX942; Dusquetide (USAN/INN); L-arginyl-L-isoleucyl-L-valyl-L-prolyl-L-alaninamide; SGX-94; CHEMBL3545314; SCHEMBL16671001; IMX-942; SGX-942; HY-P2076; CS-0107857; J3.575.671J; D11751; Q27280772; (2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Oral cavity squamous cell carcinoma	2B6E.0	Phase 3	[1]
Oral mucositis	DA01.11	Phase 3	[1]
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Drug Type

Peptide

Structure

3D MOL is unavailable

2D MOL

Chemical Identifiers

Formula: C25H47N9O5
Canonical SMILES: CCC(C)C(C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CCCN=C(N)N)N
InChI: 1S/C25H47N9O5/c1-6-14(4)19(33-21(36)16(26)9-7-11-30-25(28)29)23(38)32-18(13(2)3)24(39)34-12-8-10-17(34)22(37)31-15(5)20(27)35/h13-19H,6-12,26H2,1-5H3,(H2,27,35)(H,31,37)(H,32,38)(H,33,36)(H4,28,29,30)/t14-,15-,16-,17-,18-,19-/m0/s1
InChIKey: ZUJBBVJXXYRPFS-DYKIIFRCSA-N

Cross-matching ID

PubChem CID: 71722017
TTD ID: D3NLJ9

Repurposed Drugs (RPD)

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References

1	ClinicalTrials.gov (NCT03237325) DOM-INNATE: Study of SGX942 for the Treatment of Oral Mucositis in Patients With Concomitant Chemoradiation Therapy for Head and Neck Cancer. U.S. National Institutes of Health.