General Information of Drug (ID: DMMBH9N)

Drug Name
8-(1H-indol-5-yl)-2-morpholin-4-ylchromen-4-one
Synonyms CHEMBL200567; 8-(1H-indol-5-yl)-2-morpholin-4-ylchromen-4-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 346.4
Logarithm of the Partition Coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C21H18N2O3
IUPAC Name
8-(1H-indol-5-yl)-2-morpholin-4-ylchromen-4-one
Canonical SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC5=C(C=C4)NC=C5
InChI
InChI=1S/C21H18N2O3/c24-19-13-20(23-8-10-25-11-9-23)26-21-16(2-1-3-17(19)21)14-4-5-18-15(12-14)6-7-22-18/h1-7,12-13,22H,8-11H2
InChIKey
LXMAOXUZAUDVCG-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11501108
TTD ID
D01MXN

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA-dependent protein kinase catalytic (PRKDC) TTK3PY9 PRKDC_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46.