Details of the Drug

General Information of Drug (ID: DMMGA6K)

• Drug Name: ISIS 11224

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Antisense drug
• Sequence: TCGCCTGCCTCCCTCAGCGC
• Cross-matching ID: TTD ID: D05RJQ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bcl-x messenger RNA (BCL2L1 mRNA)	TTRE6AX	B2CL1_HUMAN	Not Available	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Bcl-x messenger RNA (BCL2L1 mRNA)	DTT	BCL2L1	7.28E-13	-0.55	-0.68

References

• [1] US patent application no. 7,148,204, Antisense modulation of bcl-x expression.