Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Bioavailability: The bioavailability of drug is 28% []
  Clearance: The renal clearance of drug is 10.7 mL/min [1]
  Elimination: Following oral administration, about 60% of the dose is eliminated in the urine as unchanged ramipril (<2%) and its metabolites [2]
  Half-life: The concentration or amount of drug in body reduced by one-half in 27 - 36 hours []
  Metabolism: The drug is metabolized via the hepatic []

References

• [1] Meisel S, Shamiss A, Rosenthal T: Clinical pharmacokinetics of ramipril. Clin Pharmacokinet. 1994 Jan;26(1):7-15. doi: 10.2165/00003088-199426010-00002.
• [2] FDA Approved Products: Altace (ramipril) oral capsules