Details of the Drug

General Information of Drug (ID: DMO7492)

Drug Name

ISIS 343867

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

siRNA drug

Sequence

5'-UUUGAAAAUGWUGAUCUCC-3'

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Survivin messenger RNA (Survivin mRNA)	TTEWOHV	BIRC5_HUMAN	Not Available	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Survivin messenger RNA (Survivin mRNA)	DTT	BIRC5	1.67E-190	1.63	5.29

Molecular Expression Atlas (MEA)

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References

1	US patent application no. 7,541,344, Modulation of survivin expression.