Details of the Drug

General Information of Drug (ID: DMOD5CK)

Drug Name
L-lysine
Synonyms Enisyl
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 146.19
Logarithm of the Partition Coefficient (xlogp) -3
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Absorption
The drug is absorbed from the lumen of the small intestine into the enterocytes by an active transport process []
Metabolism
The drug is metabolized via the hepatic []
Chemical Identifiers
Formula
C6H14N2O2
IUPAC Name
(2S)-2,6-diaminohexanoic acid
Canonical SMILES
C(CCN)C[C@@H](C(=O)O)N
InChI
InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1
InChIKey
KDXKERNSBIXSRK-YFKPBYRVSA-N
Cross-matching ID
PubChem CID
5962
ChEBI ID
CHEBI:18019
CAS Number
56-87-1
DrugBank ID
DB00123
TTD ID
D07TMZ
VARIDT ID
DR00115

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
G-protein coupled receptor GPCR33 (GPRC6A) TTI1PRE GPC6A_HUMAN Agonist [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Mitochondrial ornithine transporter 3 (SLC25A29) DT96BT4 MCATL_HUMAN Substrate [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 724).
2 Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol. 2005 Mar;67(3):589-97.
3 The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84.