| Drug Name |
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| Synonyms |
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| #Ro5 Violations (Lipinski): 1 |
Molecular Weight (mw) |
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| Logarithm of the Partition Coefficient (xlogp) |
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| Rotatable Bond Count (rotbonds) |
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| Hydrogen Bond Donor Count (hbonddonor) |
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| Hydrogen Bond Acceptor Count (hbondacc) |
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| ADMET Property |
- Absorption Cmax
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The maximum plasma concentration (Cmax) of drug is 65-128 mcg/L
[1]
- Absorption Tmax
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The time to maximum plasma concentration (Tmax) is 0.5 h
[1]
- Bioavailability
-
The bioavailability of drug is 67-114%
[1]
- Clearance
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The total plasma clearance of drug is 0.35-1 L/h/kg
[1]
- Elimination
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50% of a dose is recovered in the urine as unchanged chloroquine, with 10% of the dose recovered in the urine as desethylchloroquine
[1]
- Half-life
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The concentration or amount of drug in body reduced by one-half in 20 - 60 days
[1]
- Metabolism
-
The drug is metabolized via the CYP2C8 and CYP3A4 to N-desethylchloroquine
[1]
- Vd
-
The volume of distribution (Vd) of drug is 200-800 L/kg
[1]
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| Cross-matching ID |
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