Details of the Drug

General Information of Drug (ID: DMOTXP1)

• Drug Name: Hydantocidin-5'-Monophosphate
• Synonyms: Hydantocidin-5'-phosphate; HYDANTOCIDIN-5'-PHOSPHATE; PHOSPHOHYDANTOCIDIN; CHEMBL323799; H5P; 1juy; HYDANTOCIDIN-5'-MONOPHOSPHATE; 5'-phosphohydantocidin; AC1L9JTE; HYDANTOCIDIN-5''-PHOSPHATE; BDBM50149203; HYDANTOCIDIN-5''-MONOPHOSPHATE; DB02493; HNP; Phosphoric acid mono-((5S,7R,8S,9R)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diaza-spiro[44]non-7-ylmethyl) ester; [(1R,2S,3R,5S)-1,2-dihydroxy-6,8-dioxo-4-oxa-7,9-diazaspiro[44]nonan-3-yl]methyl dihydrogen phosphate; [(5S,7R,8S,9R)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diazaspiro[44]non-7-yl]methyl; Hydantocidin-5'-Phosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 2:
  Molecular Weight (mw); 298.14
  Logarithm of the Partition Coefficient (xlogp); -4.4
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 6
  Hydrogen Bond Acceptor Count (hbondacc); 9
• Chemical Identifiers:
  Formula: C7H11N2O9P
  IUPAC Name: [(5S,7R,8S,9R)-8,9-dihydroxy-2,4-dioxo-6-oxa-1,3-diazaspiro[4.4]nonan-7-yl]methyl dihydrogen phosphate
  Canonical SMILES: C([C@@H]1[C@H]([C@H]([C@]2(O1)C(=O)NC(=O)N2)O)O)OP(=O)(O)O
  InChI: InChI=1S/C7H11N2O9P/c10-3-2(1-17-19(14,15)16)18-7(4(3)11)5(12)8-6(13)9-7/h2-4,10-11H,1H2,(H2,14,15,16)(H2,8,9,12,13)/t2-,3-,4-,7+/m1/s1
  InChIKey: HVXIMXHBUJADCC-GTBMBKLPSA-N
• Cross-matching ID:
  PubChem CID: 446561
  DrugBank ID: DB02493
  TTD ID: D0VW5G

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Adenylosuccinate synthetase (Malaria Adss)	TTYQ4AE	PURA_PLAFA	Inhibitor	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.