Details of the Drug

General Information of Drug (ID: DMOUW65)

Drug Name
Pegunigalsidase alfa
Synonyms PRX-102; Galactosidase enzyme replacement therapy (Fabry disease), Protalix
Indication
Disease Entry ICD 11 Status REF
Fabry disease 5C56.01 Approved [1]
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 5 Molecular Weight (mw) 560.6
Logarithm of the Partition Coefficient (xlogp) -8
Rotatable Bond Count (rotbonds) 24
Hydrogen Bond Donor Count (hbonddonor) 8
Hydrogen Bond Acceptor Count (hbondacc) 11
Chemical Identifiers
Formula
C24H44N6O9
IUPAC Name
(2S)-2-amino-6-[[4-[2-[2-[[4-[[(5S)-5-amino-5-carboxypentyl]amino]-4-oxobutanoyl]amino]ethoxy]ethylamino]-4-oxobutanoyl]amino]hexanoic acid
Canonical SMILES
C(CCNC(=O)CCC(=O)NCCOCCNC(=O)CCC(=O)NCCCC[C@@H](C(=O)O)N)C[C@@H](C(=O)O)N
InChI
InChI=1S/C24H44N6O9/c25-17(23(35)36)5-1-3-11-27-19(31)7-9-21(33)29-13-15-39-16-14-30-22(34)10-8-20(32)28-12-4-2-6-18(26)24(37)38/h17-18H,1-16,25-26H2,(H,27,31)(H,28,32)(H,29,33)(H,30,34)(H,35,36)(H,37,38)/t17-,18-/m0/s1
InChIKey
CQPWQUAJPPFCDP-ROUUACIJSA-N
Cross-matching ID
PubChem CID
121488171
CAS Number
1644392-61-9
TTD ID
D07URD

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Alpha-galactosidase A (GLA) TTIS03D AGAL_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761161.
2 Characterization of a chemically modified plant cell culture expressed human alpha-Galactosidase-A enzyme for treatment of Fabry disease. Mol Genet Metab. 2015 Feb;114(2):259-67.