Details of the Drug

General Information of Drug (ID: DMPD8O2)

Drug Name

FK-960

Synonyms

UNII-2GB92V6H2O; 2GB92V6H2O; FK-960; FK-960 hydrate; FK-960 monohydrate; AC1OCFBG; SCHEMBL3089403; FR-59960; LS-25245; N-(4-acetylpiperazin-1-yl)-4-fluorobenzamide hydrate; Benzamide, N-(4-acetyl-1-piperazinyl)-4-fluoro-, hydrate (1:1)

Indication

Disease Entry	ICD 11	Status	REF
Cognitive impairment	6D71	Discontinued in Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

265.28

Logarithm of the Partition Coefficient (xlogp)

0.8

Rotatable Bond Count (rotbonds)

2

Hydrogen Bond Donor Count (hbonddonor)

1

Hydrogen Bond Acceptor Count (hbondacc)

4

Chemical Identifiers

Formula: C13H16FN3O2
IUPAC Name: N-(4-acetylpiperazin-1-yl)-4-fluorobenzamide
Canonical SMILES: CC(=O)N1CCN(CC1)NC(=O)C2=CC=C(C=C2)F
InChI: InChI=1S/C13H16FN3O2/c1-10(18)16-6-8-17(9-7-16)15-13(19)11-2-4-12(14)5-3-11/h2-5H,6-9H2,1H3,(H,15,19)
InChIKey: XTOKQKWTUYYVAO-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 181428
CAS Number: 133920-70-4
DrugBank ID: DB06465
TTD ID: D00RMD

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Somatostatin receptor (SSTR)	TTOMNR9	NOUNIPROTAC	Modulator	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008887)
2	FK960, a novel potential anti-dementia drug, enhances high K(+)-evoked release of somatostatin from rat hippocampal slices. Brain Res. 2001 Feb 16;892(1):111-7.