Details of the Drug | DrugMAP

General Information of Drug (ID: )

Drug Name
Synonyms
#Ro5 Violations (Lipinski): 1	Molecular Weight (mw)
	Logarithm of the Partition Coefficient (xlogp)
	Rotatable Bond Count (rotbonds)
	Hydrogen Bond Donor Count (hbonddonor)
	Hydrogen Bond Acceptor Count (hbondacc)
ADMET Property	BDDCS Class Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [1] Clearance The drug present in the plasma can be removed from the body at the rate of 1.6 mL/min/kg [2] Elimination 60% of drug is excreted from urine in the unchanged form [1] Half-life The concentration or amount of drug in body reduced by one-half in 39 hours [2] MRTD The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.91445 micromolar/kg/day [3] Unbound Fraction The unbound fraction of drug in plasma is 0.62% [2] Vd Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 0.38 L/kg [2]
Cross-matching ID

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Benzyl alcohol	E00010	244	Antimicrobial preservative; Solvent
Sodium chloride	E00077	5234	Diluent; Tonicity agent
Sodium hydroxide	E00234	14798	Alkalizing agent
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Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Enalaprilat 1.25mg/ml injectable	1.25mg/ml	Injectable	Injection

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References

1	BDDCS applied to over 900 drugs
2	Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3	Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose