Details of the Drug

General Information of Drug (ID: DMQ4HUA)

Drug Name
CAB-2
Synonyms MLN2222
Indication
Disease Entry ICD 11 Status REF
Coronary artery disease BA80 Discontinued in Phase 1 [1]
Cross-matching ID
TTD ID
D0Q0OP

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Complement factor B (CFB) TTA0P7K CFAB_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Coronary artery disease
ICD Disease Classification BA80
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Complement factor B (CFB) DTT CFB 1.63E-02 0.07 0.13
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010210)
2 A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation. 2002 Mar;9(2):125-34.