Details of the Drug

General Information of Drug (ID: DMQB8TW)

• Drug Name: Mimosine
• Synonyms: Mimosine; Leucenol; 10182-82-8; WZNJWVWKTVETCG-UHFFFAOYSA-N; NSC69188; NSC159548; 1(4H)-Pyridinealanine, 3-hydroxy-4-oxo-; beta-[N-(3-Hydroxy-4-pyridone)]-alpha-aminopropionic Acid; 1(4H)-Pyridinepropanoic acid, .alpha.-amino-3-hydroxy-4-oxo-, (.alpha.S)-; beta-(N-(3-Hydroxy-4-pyridone))-alpha-aminopropionic acid; Prestwick_830; Spectrum_000287; AC1L1GVQ; Spectrum4_000110; Prestwick0_000379; Mimosine, (+/-)-; Spectrum2_000656; Spectrum3_000722; Prestwick2_000379; Spectrum5_001484; Prestwick1_000379
• Affected Organisms: Humans and other mammals
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 198.18
  Logarithm of the Partition Coefficient (xlogp); -3.5
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 6
• Chemical Identifiers:
  Formula: C8H10N2O4
  IUPAC Name: 2-amino-3-(3-hydroxy-4-oxopyridin-1-yl)propanoic acid
  Canonical SMILES: C1=CN(C=C(C1=O)O)CC(C(=O)O)N
  InChI: InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)
  InChIKey: WZNJWVWKTVETCG-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 3862
  ChEBI ID: CHEBI:95190
  CAS Number: 2116-55-4
  UNII: Z46B1LUI5N
  DrugBank ID: DB01055
  TTD ID: D04ZWL

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Serine hydroxymethyltransferase (Malaria SHMT)	TTO8YH2	Q8I566_PLAF7	Inhibitor	[1]

References

• [1] Mimosine targets serine hydroxymethyltransferase. J Biol Chem. 1996 Feb 2;271(5):2548-56.