Details of the Drug

General Information of Drug (ID: DMQRO6G)

• Drug Name: US8546370, 102
• Synonyms: SCHEMBL1043246; CHEMBL3639414; BDBM103514; US8546370, 102
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 432.9
  Logarithm of the Partition Coefficient (xlogp); 4.2
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C24H21ClN4O2
  IUPAC Name: 6-(2-chlorophenyl)-8-(4-morpholin-4-ylanilino)-2H-2,7-naphthyridin-1-one
  Canonical SMILES: C1COCCN1C2=CC=C(C=C2)NC3=C4C(=CC(=N3)C5=CC=CC=C5Cl)C=CNC4=O
  InChI: InChI=1S/C24H21ClN4O2/c25-20-4-2-1-3-19(20)21-15-16-9-10-26-24(30)22(16)23(28-21)27-17-5-7-18(8-6-17)29-11-13-31-14-12-29/h1-10,15H,11-14H2,(H,26,30)(H,27,28)
  InChIKey: BMPOWIIBXCMAFL-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 58094043
  TTD ID: D00HGD

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine-protein kinase ZAP-70 (ZAP-70)	TTUMHT8	ZAP70_HUMAN	Inhibitor	[1]

References

• [1] Compounds and compositions as kinase inhibitors. US8546370.