Details of the Drug

General Information of Drug (ID: DMRL900)

Drug Name

LAF-389

Synonyms

Bengamide B, Novartis; Bengamide E, Novartis; Bengamides, Novartis; Anticancer therapy (ciclosporin derivatives), Novartis; Anticancer therapy (cyclosporin A derivatives), Novartis; Anticancer therapy (cyclosporine derivatives), Novartis

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[1]
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Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C25H42N2O8
Canonical SMILES: CC(C)(C)C=CC(C(C(C(C(=O)NC1CCC(CNC1=O)OC(=O)C2CCCCC2)OC)O)O)O
InChI: 1S/C25H42N2O8/c1-25(2,3)13-12-18(28)19(29)20(30)21(34-4)23(32)27-17-11-10-16(14-26-22(17)31)35-24(33)15-8-6-5-7-9-15/h12-13,15-21,28-30H,5-11,14H2,1-4H3,(H,26,31)(H,27,32)/b13-12+/t16-,17+,18-,19+,20-,21-/m1/s1
InChIKey: XSYJUVKQRPLTAU-BKMGADMVSA-N

Cross-matching ID

PubChem CID: 9892113
TTD ID: D06WEB

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017972)