Details of the Drug

General Information of Drug (ID: DMRSX53)

Drug Name

nusinersen

Synonyms

BIIB 058; IONIS-SMNRx; ISIS-396443; Spinraza

Indication

Disease Entry	ICD 11	Status	REF
Spinal muscular atrophy	8B61	Approved	[1]
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Drug Type

Antisense drug

Sequence

UCACUUUCAUAAUGCUGG

Structure

3D MOL is unavailable

2D MOL

ADMET Property

Clearance: The drug is slowly cleared []
Half-life: The concentration or amount of drug in body reduced by one-half in 135 - 177 days []
Metabolism: The drug is metabolized via the exonuclease (3- and 5)-mediated hydrolysis primarily at the 3' end of the oligonucleotide [2]
Vd: The volume of distribution (Vd) of drug is 29 L []

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
2	CENTER FOR DRUG EVALUATION AND RESEARCH