Details of the Drug

General Information of Drug (ID: DMSMQGL)

Drug Name

GSK3494245

Synonyms

GSK3494245; DDD01305143; GSK-3494245; DDD-01305143; T7XAE9Y6B9; 2080410-41-7; N-(4-Fluoro-3-(3-morpholinoimidazo(1,2-a)pyrimidin-7-yl)phenyl)pyrrolidine-1-carboxamide; N-(4-fluoro-3-(3-morpholinoimidazo[1,2-a]pyrimidin-7-yl)phenyl)pyrrolidine-1-carboxamide; 1-Pyrrolidinecarboxamide, N-(4-fluoro-3-(3-(4-morpholinyl)imidazo(1,2-a)pyrimidin-7-yl)phenyl)-; N-(4-Fluoro-3-(3-(4-morpholinyl)imidazo(1,2-a)pyrimidin-7-yl)phenyl)-1-pyrrolidinecarboxamide; UNII-T7XAE9Y6B9; CHEMBL5095239; SCHEMBL18495650; BDBM50601512; MS-27077; HY-127102; CS-0093101; GSK3494245/DDD01305143

Indication

Disease Entry	ICD 11	Status	REF
Visceral leishmaniasis	1F54.0	Phase 1	[1]
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Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C21H23FN6O2
Canonical SMILES: C1CCN(C1)C(=O)NC2=CC(=C(C=C2)F)C3=NC4=NC=C(N4C=C3)N5CCOCC5
InChI: InChI=1S/C21H23FN6O2/c22-17-4-3-15(24-21(29)27-6-1-2-7-27)13-16(17)18-5-8-28-19(14-23-20(28)25-18)26-9-11-30-12-10-26/h3-5,8,13-14H,1-2,6-7,9-12H2,(H,24,29)
InChIKey: SAJUCKZZYFFICP-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 126571915
TTD ID: DM8RI3

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proteasome (PS)	TTU7ZMG	NOUNIPROTAC	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT04504435) A Randomized, Double-blind, Placebo-controlled, First Time in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single (in Both Fed and Fasted States) Doses of GSK3494245 in Healthy Participants. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of GlaxoSmithKline