Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 25-50 mg/L [1]
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1 h [1]
  Elimination: Approximately 50% of streptomycin is eliminated in the urine within 24 hours after intravenous or intramuscular administration [2]
  Half-life: The concentration or amount of drug in body reduced by one-half in 2.5 hours [3]

References

• [1] DailyMed Drug Label Information: Streptomycin injection
• [2] Buggs CW, Pilling MA, Bronstein B, Hirshfeld JW, Worzniak L, Key LJ: THE ABSORPTION, DISTRIBUTION, AND EXCRETION OF STREPTOMYCIN IN MAN. J Clin Invest. 1946 Jan;25(1):94-102. doi: 10.1172/JCI101693.
• [3] Streptomycin .