General Information of Drug (ID: DMTJOWH)

Drug Name
CP-339818
Synonyms
CHEMBL281622; AC1LCVJB; CP 339818; Tocris-1399; C13847; (1-Benzyl-1H-quinolin-4-ylidene)-pentyl-amine; SureCN12648579; GTPL2558; SCHEMBL12648579; CHEBI:34602; 1-benzyl-N-pentylquinolin-4-imine; 1-benzyl-N-pentyl-quinolin-4-imine; ZINC17919916; BDBM50083523; ZINC100002080; ZINC253533285; NCGC00025144-01; AJ-70179; CP339818; AJ-70180; N-pentyl-1-(phenylmethyl)quinolin-4-imine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 304.4
Logarithm of the Partition Coefficient (xlogp) 5.1
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C21H24N2
IUPAC Name
1-benzyl-N-pentylquinolin-4-imine
Canonical SMILES
CCCCCN=C1C=CN(C2=CC=CC=C12)CC3=CC=CC=C3
InChI
InChI=1S/C21H24N2/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21/h4-8,10-14,16H,2-3,9,15,17H2,1H3
InChIKey
MMGAVKCAGQCFHS-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
656767
ChEBI ID
CHEBI:34602
CAS Number
185855-91-8
TTD ID
D0E9MC

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated potassium channel Kv1.3 (KCNA3) TTY3UE6 KCNA3_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2558).
2 Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. J Med Chem. 2001 Apr 12;44(8):1249-56.