Details of the Drug

General Information of Drug (ID: DMTRDPI)

• Drug Name: Bicine
• Synonyms: Bicine; 150-25-4; N,N-Bis(2-hydroxyethyl)glycine; Diethylolglycine; Dihydroxyethylglycine; 2-(bis(2-hydroxyethyl)amino)acetic acid; Diethanol glycine; N,N-Di(2-hydroxyethyl)glycine; Bicene; N,N-Dihydroxyethylglycine; N,N-Dihydroxyethyl glycine; Fe-3-Specific; DHEG; Glycine, N,N-bis(2-hydroxyethyl)-; Bis(2-Hydroxyethyl)glycine; N,N-(2-Hydroxyethyl)glycine; 2-[bis(2-hydroxyethyl)amino]acetic acid; N,N-Bis(2-hydroxyethyl)aminoacetic acid; N,N-Bis(beta-hydroxyethyl)glycine; NSC 7342; GLYCINE, N,N-DIHYDROXYETHYL-; UNII-1J484QFI1O

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 163.17
  Logarithm of the Partition Coefficient (xlogp); -3.8
  Rotatable Bond Count (rotbonds); 6
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C6H13NO4
  IUPAC Name: 2-[bis(2-hydroxyethyl)amino]acetic acid
  Canonical SMILES: C(CO)N(CCO)CC(=O)O
  InChI: InChI=1S/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)
  InChIKey: FSVCELGFZIQNCK-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 8761
  ChEBI ID: CHEBI:40957
  CAS Number: 150-25-4
  DrugBank ID: DB03709
  TTD ID: D0V2MR

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasminogen (PLG)	TTP86E2	PLMN_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Plasminogen (PLG)	DTT	PLG	8.61E-01	-0.01	-0.09

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.