| Drug Name |
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| Synonyms |
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| #Ro5 Violations (Lipinski): 1 |
Molecular Weight (mw) |
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| Logarithm of the Partition Coefficient (xlogp) |
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| Rotatable Bond Count (rotbonds) |
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| Hydrogen Bond Donor Count (hbonddonor) |
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| Hydrogen Bond Acceptor Count (hbondacc) |
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| ADMET Property |
- Absorption Cmax
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The maximum plasma concentration (Cmax) of drug is 14.4 +/- 5.3 mcg/L
[1]
- Absorption Tmax
-
The time to maximum plasma concentration (Tmax) is 2.1 +/- 0.8 h
[1]
- Clearance
-
The apparent oral clearance of drug is 173 +/- 50 mL/h/kg
[1]
- Elimination
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Following oral administration of [14C] sirolimus in healthy subjects, about 91% of the radioactivity was recovered from feces and only 2.2% of the radioactivity was detected in urine
[1]
- Half-life
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The concentration or amount of drug in body reduced by one-half in 62 +/- 16 hours
[1]
- Metabolism
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The drug is metabolized via the liver
[1]
- Vd
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The volume of distribution (Vd) of drug is 12 +/- 8 L/kg
[1]
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| Cross-matching ID |
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