Details of the Drug

General Information of Drug (ID: DMTZ8RQ)

• Drug Name: N-hydroxy-3-phenoxybenzamide
• Synonyms: CHEMBL245741; N-hydroxy-3-phenoxybenzamide; SCHEMBL6671653

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 229.23
  Logarithm of the Partition Coefficient (xlogp); 3.2
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C13H11NO3
  IUPAC Name: N-hydroxy-3-phenoxybenzamide
  Canonical SMILES: C1=CC=C(C=C1)OC2=CC=CC(=C2)C(=O)NO
  InChI: InChI=1S/C13H11NO3/c15-13(14-16)10-5-4-8-12(9-10)17-11-6-2-1-3-7-11/h1-9,16H,(H,14,15)
  InChIKey: WFZFBIHVPMBSOS-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 10192705
  TTD ID: D0P3SU

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone deacetylase 8 (HDAC8)	TTT6LFV	HDAC8_HUMAN	Inhibitor	[1]

References

• [1] Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8.