Details of the Drug

General Information of Drug (ID: DMTZXSO)

• Drug Name: CAR-T cells targeting Mesothelin

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

• Drug Type: CAR T Cell Therapy
• Cross-matching ID: TTD ID: D09YXN

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mesothelin (MSLN)	TT4RXME	MSLN_HUMAN	CAR-T-Cell-Therapy	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Solid tumour/cancer
• ICD Disease Classification: 2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Mesothelin (MSLN)	DTT	MSLN	2.86E-20	3.98	6.12

References

• [1] ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers