Details of the Drug

General Information of Drug (ID: DMU6JOK)

Drug Name

cirazoline

Synonyms

cirazoline; Cirazoline [INN]; Cirazolinum [INN-Latin]; Cirazolina [INN-Spanish]; UNII-QK318GVY3Y; 59939-16-1; LD-3098; QK318GVY3Y; CHEMBL13852; NCGC00015196-04; 2-((o-Cyclopropylphenoxy)methyl)-2-imidazoline; DSSTox_CID_25131; DSSTox_RID_80692; DSSTox_GSID_45131; Cirazolina; Cirazolinum; 1H-Imidazole, 2-((2-cyclopropylphenoxy)methyl)-4,5-dihydro-; 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole; CAS-59939-16-1; LD 3098; Tocris-0888; Lopac-C-223; AC1L1EEZ; Lopac0_000354; KBioGR_000306; BSPBio_001586; KBioSS_000306; GTPL515

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

216.28

Logarithm of the Partition Coefficient (xlogp)

1.8

Rotatable Bond Count (rotbonds)

4

Hydrogen Bond Donor Count (hbonddonor)

1

Hydrogen Bond Acceptor Count (hbondacc)

2

Chemical Identifiers

Formula: C13H16N2O
IUPAC Name: 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole
Canonical SMILES: C1CC1C2=CC=CC=C2OCC3=NCCN3
InChI: InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
InChIKey: YAORIDZYZDUZCM-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 2765
ChEBI ID: CHEBI:92950
CAS Number: 59939-16-1
DrugBank ID: DB09202
TTD ID: D06QKW

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Agonist	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 515).
2	Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.