Details of the Drug

General Information of Drug (ID: DMUPL0W)

• Drug Name: PMID25514969-Compound-11
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 342.32
  Logarithm of the Partition Coefficient (xlogp); 2
  Rotatable Bond Count (rotbonds); 2
  Hydrogen Bond Donor Count (hbonddonor); 0
  Hydrogen Bond Acceptor Count (hbondacc); 6
• Chemical Identifiers:
  Formula: C17H15FN4O3
  IUPAC Name: [6-fluoro-8-(1,3-oxazol-5-yl)imidazo[1,2-a]pyridin-3-yl]-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)methanone
  Canonical SMILES: C1CC2COCC1N2C(=O)C3=CN=C4N3C=C(C=C4C5=CN=CO5)F
  InChI: InChI=1S/C17H15FN4O3/c18-10-3-13(15-5-19-9-25-15)16-20-4-14(21(16)6-10)17(23)22-11-1-2-12(22)8-24-7-11/h3-6,9,11-12H,1-2,7-8H2
  InChIKey: AVXVHVNSDORSDK-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 118379012
  TTD ID: D0LW9K

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholesterol 24-hydroxylase (CYP46A1)	TT4EB85	CP46A_HUMAN	Inhibitor	[1]

References

• [1] Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7.