Details of the Drug

General Information of Drug (ID: DMUV8OR)

Drug Name
Indecainide
Synonyms
Indecainida; Indecainidum; Ricainid; Ricainide; Indecainida [Spanish]; Indecainide [INN]; Indecainidum [Latin]; Decabid (TN); LY-135837; 9-(3-((1-methylethyl)amino)propyl)-9H-fluorene-9-carboxamide; 9-(3-(Isopropylamino)propyl))fluorene-9-carboxamide; 9-(3-(Isopropylamino)propyl)-9-fluorenylcarboxamid; 9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide
Indication
Disease Entry ICD 11 Status REF
Dysrhythmias BC9Z Approved [1]
Therapeutic Class
Antidysrhythmic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 308.4
Logarithm of the Partition Coefficient (xlogp) 3
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 2
ADMET Property
Absorption
The drug is nearly complete absorbed following oral administration []
Chemical Identifiers
Formula
C20H24N2O
IUPAC Name
9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide
Canonical SMILES
CC(C)NCCCC1(C2=CC=CC=C2C3=CC=CC=C31)C(=O)N
InChI
InChI=1S/C20H24N2O/c1-14(2)22-13-7-12-20(19(21)23)17-10-5-3-8-15(17)16-9-4-6-11-18(16)20/h3-6,8-11,14,22H,7,12-13H2,1-2H3,(H2,21,23)
InChIKey
UCEWGESNIULAGX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
52195
ChEBI ID
CHEBI:135314
CAS Number
74517-78-5
DrugBank ID
DB00192
TTD ID
D0K4CQ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.5 (SCN5A) TTZOVE0 SCN5A_HUMAN Blocker [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019693.
2 Electrophysiological studies of indecainide hydrochloride, a new antiarrhythmic agent, in canine cardiac tissues. J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):614-21.