Details of the Drug

General Information of Drug (ID: DMVBQ2L)

Drug Name

SGN LIV1A

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 1	[1]
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Drug Type

Antibody

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 39 member 6 (SLC39A6)	TTZN1CF	S39A6_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

ICD Disease Classification

02 Neoplasm

Disease Class

ICD-11: 2C82 Prostate cancer

The Studied Tissue

Breast tissue

The Studied Disease

Breast cancer [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Solute carrier family 39 member 6 (SLC39A6)	DTT	SLC39A6	3.54E-08	0.26	0.25

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT01969643) A Safety Study of SGN-LIV1A in Breast Cancer Patients. U.S. National Institutes of Health.
2	SGN-LIV1A: a novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer. Mol Cancer Ther. 2014 Dec;13(12):2991-3000.