Details of the Drug

General Information of Drug (ID: DMWIKD5)

• Drug Name: ISIS 14144

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Antisense drug
• Sequence: GGACAGGAAACGCACCATA
• Cross-matching ID: TTD ID: D07TDZ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B-Raf messenger RNA (BRAF mRNA)	TT0EOB8	BRAF_HUMAN	Not Available	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
B-Raf messenger RNA (BRAF mRNA)	DTT	BRAF	1.56E-01	-0.23	-0.43

References

• [1] US patent application no. 5,981,731, Antisense oligonucleotide modulation of B-raf gene expression.