Details of the Drug

General Information of Drug (ID: DMWVYDN)

Drug Name

Radavirsen

Synonyms

AVI-7100; AVI-7367; H1N1 influenza virus inhibitor (antisense), AVI Biopharma

Indication

Disease Entry	ICD 11	Status	REF
Influenza virus infection	1E30-1E32	Phase 1	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C253H398N116O87P20
Canonical SMILES: CC1=CN(C(=O)NC1=O)C2CNCC(O2)COP(=O)(N3CC(OC(C3)N4C=C(C(=O)NC4=O)C)COP(=O)(N5CC(OC(C5)N6C=C(C(=O)NC6=O)C)COP(=O)(N7CCNCC7)N8CC(OC(C8)N9C=CC(=NC9=O)N)COP(=O)(N1CC(OC(C1)N1C=C(C(=O)NC1=O)C)COP(=O)(N1CC(OC(C1)N1C=NC2=C(N=CN=C21)N)COP(=O)(N1CC(OC(C1)N1C=CC(=NC1=O)N)COP(=O)(N1CC(OC(C1)N1C=C(C(=O)NC1=O)C)COP(=O)(N1CCNCC1)N1CC(OC(C1)N1C=CC(=NC1=O)N)COP(=O)(N1CC(OC(C1)N1C=NC2=C(N=CN=C21)N)COP(=O)(N1CC(OC(C1)N1C=NC2=C1N=C(NC2=O)N)COP(=O)(N1CC(OC(C1)N1C=NC2=C(N=CN=C21)N)COP(=O)(N1CC(OC(C1)N1C=NC2=C(N=CN=C21)N)COP(=O)(N1CC(OC(C1)N1C=NC2=C1N=C(NC2=O)N)COP(=O)(N1CC(OC(C1)N1C=NC2=C(N=CN=C21)N)COP(=O)(N1CC(OC(C1)N1C=C(C(=O)NC1=O)C)COP(=O)(N1CCNCC1)N1CC(OC(C1)N1C=C(C(=O)NC1=O)C)COP(=O)(N1CC(OC(C1)N1C=NC2=C1N=C(NC2=O)N)COP(=O)(N1CC(OC(C1)N1C=NC2=C1N=C(NC2=O)N)COP(=O)(N1CC(OC(C1)N1C=CC(=NC1=O)N)COP(=O)(N1CCN(CC1)C(=O)OCCOCCOCCO)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C)N(C)C
InChI: 1S/C253H398N116O87P20/c1-153-74-354(246(386)302-227(153)371)184-73-270-72-160(437-184)119-417-458(395,310(10)11)333-83-163(442-189(104-333)355-75-154(2)228(372)303-247(355)387)122-420-463(400,315(20)21)336-95-175(445-192(107-336)358-78-157(5)231(375)306-250(358)390)137-435-474(411,327-56-46-267-47-57-327)347-97-177(440-187(102-347)352-54-44-182(256)292-244(352)384)133-431-461(398,313(16)17)334-84-164(443-190(105-334)356-76-155(3)229(373)304-248(356)388)123-421-465(402,317(24)25)338-85-165(448-195(110-338)361-144-281-204-213(258)271-139-276-218(204)361)124-422-460(397,312(14)15)332-82-162(439-186(101-332)351-53-43-181(255)291-243(351)383)121-419-462(399,314(18)19)335-94-174(444-191(106-335)357-77-156(4)230(374)305-249(357)389)136-434-475(412,328-58-48-268-49-59-328)348-98-178(441-188(103-348)353-55-45-183(257)293-245(353)385)134-432-469(406,321(32)33)342-89-169(452-199(114-342)365-148-285-208-217(262)275-143-280-222(208)365)128-427-471(408,323(36)37)344-92-172(455-202(116-344)368-151-288-211-225(368)296-240(265)300-236(211)380)131-429-468(405,320(30)31)341-87-167(450-198(113-341)364-147-284-207-216(261)274-142-279-221(207)364)126-425-466(403,318(26)27)339-88-168(451-197(111-339)363-146-283-206-215(260)273-141-278-220(206)363)127-426-470(407,322(34)35)343-91-171(454-201(115-343)367-150-287-210-224(367)295-239(264)299-235(210)379)130-428-467(404,319(28)29)340-86-166(449-196(112-340)362-145-282-205-214(259)272-140-277-219(205)362)125-424-464(401,316(22)23)337-96-176(446-193(108-337)359-79-158(6)232(376)307-251(359)391)138-436-476(413,329-60-50-269-51-61-329)349-99-179(447-194(109-349)360-80-159(7)233(377)308-252(360)392)135-433-473(410,325(40)41)346-93-173(456-203(118-346)369-152-289-212-226(369)297-241(266)301-237(212)381)132-430-472(409,324(38)39)345-90-170(453-200(117-345)366-149-286-209-223(366)294-238(263)298-234(209)378)129-423-459(396,311(12)13)331-81-161(438-185(100-331)350-52-42-180(254)290-242(350)382)120-418-457(394,309(8)9)330-64-62-326(63-65-330)253(393)416-71-70-415-69-68-414-67-66-370/h42-45,52-55,74-80,139-152,160-179,184-203,267-270,370H,46-51,56-73,81-138H2,1-41H3,(H2,254,290,382)(H2,255,291,383)(H2,256,292,384)(H2,257,293,385)(H2,258,271,276)(H2,259,272,277)(H2,260,273,278)(H2,261,274,279)(H2,262,275,280)(H,302,371,386)(H,303,372,387)(H,304,373,388)(H,305,374,389)(H,306,375,390)(H,307,376,391)(H,308,377,392)(H3,263,294,298,378)(H3,264,295,299,379)(H3,265,296,300,380)(H3,266,297,301,381)/t160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,184+,185+,186+,187+,188+,189+,190+,191+,192+,193+,194+,195+,196+,197+,198+,199+,200+,201+,202+,203+,457?,458?,459?,460?,461?,462?,463?,464?,465?,466?,467?,468?,469?,470?,471?,472?,473?,474?,475?,476?/m0/s1
InChIKey: UGGITRSRFHZMKU-WEIZIPMPSA-N

Cross-matching ID

PubChem CID: 56843929
CAS Number: 1228284-45-4
TTD ID: D02VER

References

1	ClinicalTrials.gov (NCT01747148) Testing the AVI-7100 Flu Drug in Healthy Volunteers. U.S. National Institutes of Health.