Details of the Drug

General Information of Drug (ID: DMWX4L5)

• Drug Name: 3-(trifluoromethyl)-9H-carbazole
• Synonyms: 3-(trifluoromethyl)-9H-carbazole; 2467-83-6; CHEMBL1170444; 3-trifluoromethyl-9H-carbazole; SCHEMBL4130017; JGFJDDMRCMCZMU-UHFFFAOYSA-N; CS-B1171; 9H-Carbazole, 3-(trifluoromethyl)-; BDBM50322575; ZINC53243063

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 235.2
  Logarithm of the Partition Coefficient (xlogp); 4.6
  Rotatable Bond Count (rotbonds); 0
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C13H8F3N
  IUPAC Name: 3-(trifluoromethyl)-9H-carbazole
  Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C=CC(=C3)C(F)(F)F
  InChI: InChI=1S/C13H8F3N/c14-13(15,16)8-5-6-12-10(7-8)9-3-1-2-4-11(9)17-12/h1-7,17H
  InChIKey: JGFJDDMRCMCZMU-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 42611896
  TTD ID: D09MXK

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kinesin spindle messenger RNA (KIF11 mRNA)	TTBGTCW	KIF11_HUMAN	Inhibitor	[1]

References

• [1] Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8.