General Information of Drug (ID: DMWYIJ3)

Drug Name
L-708,906
Synonyms
L-708906; CHEMBL19977; SCHEMBL4935528; L-708,906; AC1L9T47; CTK7I3759; BDBM107681; 4-(3,5-dibenzyloxyphenyl)-2,4-dioxo-butanoic acid; 4-[3,5-bis(benzyloxy)phenyl]-2,4-dioxobutanoic acid; 4-(3,5-Bis-benzyloxy-phenyl)-2,4-dioxo-butyric acid; 4-[3,5-bis(phenylmethoxy)phenyl]-2,4-dioxobutanoic acid; (2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxobut-2-enoic acid (Compound 2)
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 404.4
Logarithm of the Partition Coefficient (xlogp) 4.1
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C24H20O6
IUPAC Name
4-[3,5-bis(phenylmethoxy)phenyl]-2,4-dioxobutanoic acid
Canonical SMILES
C1=CC=C(C=C1)COC2=CC(=CC(=C2)C(=O)CC(=O)C(=O)O)OCC3=CC=CC=C3
InChI
InChI=1S/C24H20O6/c25-22(14-23(26)24(27)28)19-11-20(29-15-17-7-3-1-4-8-17)13-21(12-19)30-16-18-9-5-2-6-10-18/h1-13H,14-16H2,(H,27,28)
InChIKey
SLRLQBRWUMWEOZ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
475514
TTD ID
D01HGV

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human immunodeficiency virus Integrase (HIV IN) TT5FH9Y POL_HV1B1 Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase. Antimicrob Agents Chemother. 2001 Sep;45(9):2510-6.