Details of the Drug

General Information of Drug (ID: DMX2Y51)

Drug Name

CC-99282

Synonyms

Golcadomide; CC-99282; Golcadomide [USAN]; 29HLR8Z5BR; 2379572-34-4; UNII-29HLR8Z5BR; CC99282; CC1007548; WHO 12305; (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 2-((3S)-2,6-dioxo-3-piperidinyl)-4-(((2-fluoro-4-((3-(4-morpholinyl)-1-azetidinyl)methyl)phenyl)methyl)amino)-; golcadomide [INN]; CHEMBL5095226; SCHEMBL21492854; GTPL13021; EX-A6835; CC 99282 [WHO-DD]; Cc 99282; compound 1 [US20220324855]; MS-29895; HY-146237; CS-0530225; EN300-43359175; (8(3)S)-4(3)-fluoro-6-aza-7(4,2)-isoindola-1(4)-morpholina-8(3)-piperidina-2(3,1)-azetidina-4(1,4)-benzenaoctaphane-7(1),7(3),8(2),8-tetrone; (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1- yl)methyl)benzyl)amino)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-4-[[[2-fluoro-4-[[3-(4- morpholinyl)-1-azetidinyl]methyl]phenyl]methyl]amino]-; 2-((3S)-2,6-DIOXOPIPERIDIN-3-YL)-4-(((2-FLUORO-4-((3-(MORPHOLIN-4-YL)AZETIDIN-1-YL)METHYL) PHENYL) METHYL)AMINO)-1H-ISOINDOLE-1,3(2H)-DIONE; 2-[(3S)-2,6-dioxopiperidin-3-yl]-4-[[2-fluoro-4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methylamino]isoindole-1,3-dione; 2-[(3S)-2,6-dioxopiperidin-3-yl]-4-{[(2-fluoro-4-{[3-(morpholin-4-yl)azetidin-1-yl]methyl}phenyl)methyl]amino}-2,3-dihydro-1H-isoindole-1,3-dione

Indication

Disease Entry	ICD 11	Status	REF
Non-hodgkin lymphoma	2B33.5	Phase 2	[1]
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Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C28H30FN5O5
Canonical SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCC4=C(C=C(C=C4)CN5CC(C5)N6CCOCC6)F
InChI: InChI=1S/C28H30FN5O5/c29-21-12-17(14-32-15-19(16-32)33-8-10-39-11-9-33)4-5-18(21)13-30-22-3-1-2-20-25(22)28(38)34(27(20)37)23-6-7-24(35)31-26(23)36/h1-5,12,19,23,30H,6-11,13-16H2,(H,31,35,36)/t23-/m0/s1
InChIKey: NZYDBVQXOGPDDU-QHCPKHFHSA-N

Cross-matching ID

PubChem CID: 146195299
TTD ID: DC51MU

References

1	ClinicalTrials.gov (NCT03930953) A Phase 1/2, Multi-center, Open-label Study to Assess the Safety, Pharmacokinetics, and Preliminary Efficacy of an Orally Available Small Molecule, CC-99282, Alone and in Combination With Anti-Lymphoma Agents in Subjects With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL). U.S.National Institutes of Health.