Details of the Drug

General Information of Drug (ID: DMXRK1D)

Drug Name

Tafamidis meglumine

Synonyms

Tafamidis meglumine; Fx-1006A; Fx1006A; Fx 1006A; UNII-ZU7CF08A1A; ZU7CF08A1A; 951395-08-7; CHEBI:79345; Tafamidis meglumine [USAN:INN]; SCHEMBL14783506; CHEMBL2105675; Tafamidis meglumine (JAN/USAN); SB16821; D-Glucitol, 1-deoxy-1-(methylamino)-, 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate; FT-0700926; D09674; 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid--1-deoxy-1-(methylamino)-D-glucitol (1/1); 1-deoxy-1-(methylazaniumyl)-D-glucitol 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate

Indication

Disease Entry	ICD 11	Status	REF
Hereditary amyloidosis	5D00.2	Approved	[1]
Transthyretin familial amyloid cardiomyopathy	5D00.20	Phase 3	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C21H24Cl2N2O8
Canonical SMILES: CNCC(C(C(C(CO)O)O)O)O.C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
InChI: 1S/C14H7Cl2NO3.C7H17NO5/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-6H,(H,18,19);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
InChIKey: DQJDBUPLRMRBAB-WZTVWXICSA-N

Cross-matching ID

PubChem CID: 24970412
ChEBI ID: CHEBI:79345
CAS Number: 951395-08-7
TTD ID: D03MGL

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2	ClinicalTrials.gov (NCT01994889) Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy. U.S. National Institutes of Health.