Details of the Drug

General Information of Drug (ID: DMXT36M)

Drug Name

Mivazerol

Synonyms

125472-02-8; Mivazerol [INN]; UNII-W5P1SSA8KD; Mivazerolum [INN-Latin]; alpha-Imidazol-4-yl-2,3-cresotamide; 2-HYDROXY-3-(1H-IMIDAZOL-4-YLMETHYL)-BENZAMIDE; W5P1SSA8KD; 3-((1H-Imidazol-4-yl)methyl)-2-hydroxybenzamide; Benzamide,2-hydroxy-3-(1H-imidazol-5-ylmethyl)-; Mivazerolum; ucb 22073; mivazerol[inn]; ACMC-20mrix; AC1L1TX2; 2-hydroxy-3-(1H-imidazol-5-ylmethyl)benzamide; SCHEMBL593707; SCHEMBL8097939; AC1Q5D40; CHEMBL2105189; CTK4B4380; DTXSID30154782; ZINC4674535; 3-((1H-imidazol-4-yl)methyl)-2-hydroxybenzamide; Closantel 6

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Discontinued in Phase 3	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

217.22

Logarithm of the Partition Coefficient (xlogp)

1.1

Rotatable Bond Count (rotbonds)

3

Hydrogen Bond Donor Count (hbonddonor)

3

Hydrogen Bond Acceptor Count (hbondacc)

3

Chemical Identifiers

Formula: C11H11N3O2
IUPAC Name: 2-hydroxy-3-(1H-imidazol-5-ylmethyl)benzamide
Canonical SMILES: C1=CC(=C(C(=C1)C(=O)N)O)CC2=CN=CN2
InChI: InChI=1S/C11H11N3O2/c12-11(16)9-3-1-2-7(10(9)15)4-8-5-13-6-14-8/h1-3,5-6,15H,4H2,(H2,12,16)(H,13,14)
InChIKey: RLHGFJMGWQXPBW-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 60784
CAS Number: 125472-02-8
TTD ID: D0V1RX

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor Alpha-2 (ADRA2)	TTQ8AFT	NOUNIPROTAC	Agonist	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002725)
2	Alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role. Anaesthesia. 1999 Feb;54(2):146-65.