General Information of Drug (ID: DMXTL7V)

Drug Name
Tetra-hydro-carboline derivative 2
Synonyms PMID28447479-Compound-29
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 471.6
Logarithm of the Partition Coefficient (xlogp) 4.1
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C29H33N3O3
IUPAC Name
4-[2-[8-[(3-ethylphenyl)methyl]-5,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),10,12-tetraen-5-yl]-2-oxoethyl]bicyclo[2.2.1]heptane-1-carboxylic acid
Canonical SMILES
CCC1=CC(=CC=C1)CN2C3=C(CCN(C3)C(=O)CC45CCC(C4)(CC5)C(=O)O)C6=C2N=CC=C6
InChI
InChI=1S/C29H33N3O3/c1-2-20-5-3-6-21(15-20)17-32-24-18-31(14-8-22(24)23-7-4-13-30-26(23)32)25(33)16-28-9-11-29(19-28,12-10-28)27(34)35/h3-7,13,15H,2,8-12,14,16-19H2,1H3,(H,34,35)
InChIKey
KFNXYFDWAKJOGZ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
66548941
TTD ID
D00PJE

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Extracellular lysophospholipase D (E-NPP2) TTSCIM2 ENPP2_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829.