| Drug Name |
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| Synonyms |
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| #Ro5 Violations (Lipinski): 1 |
Molecular Weight (mw) |
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| Logarithm of the Partition Coefficient (xlogp) |
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| Rotatable Bond Count (rotbonds) |
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| Hydrogen Bond Donor Count (hbonddonor) |
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| Hydrogen Bond Acceptor Count (hbondacc) |
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| ADMET Property |
- Absorption Tmax
-
The time to maximum plasma concentration (Tmax) is 1-2 h
[1]
- Bioavailability
-
The bioavailability of drug is 45%-55%
[1]
- Clearance
-
The clearance of drug is 96 mL/min
[2]
- Elimination
-
40-50% of hydroxychloroquine is excreted renally, while only 16-21% of a dose is excreted in the urine as unchanged drug
[2]
- Half-life
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The concentration or amount of drug in body reduced by one-half in 3 - 4 hours
[3]
- Metabolism
-
The drug is metabolized via the CYP3A4 to the active metabolite desethylhydroxychloroquine, as well as the inactive metabolites desethylchloroquine and bidesethylchloroquine
[3]
- Vd
-
The volume of distribution (Vd) of drug is 5522 L from blood and 44257 L from plasma
[2]
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| Cross-matching ID |
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