Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption AUC: The area under the plot of plasma concentration (AUC) of drug is 14,466 mcgh/L [1]
  Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 10.0 mcg/L [1]
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 4-10 h [1]
  Clearance: The renal clearance of drug is 5.9 mL/min [1]
  Elimination: An intravenous dose of promethazine is 0.64% eliminated in the urine as the unchanged parent drug [1]
  Half-life: The concentration or amount of drug in body reduced by one-half in 12 - 15 hours [1]
  Metabolism: The drug is metabolized via the CYP2D6 [2]
  Vd: The volume of distribution (Vd) of drug is 970 L or 30 L/kg [1]

References

• [1] Pharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to man. Br J Clin Pharmacol. 1983 Mar;15(3):287-93. doi: 10.1111/j.1365-2125.1983.tb01501.x.
• [2] Ahmad SR, Kortepeter C, Brinker A, Chen M, Beitz J: Renal failure associated with the use of celecoxib and rofecoxib. Drug Saf. 2002;25(7):537-44. doi: 10.2165/00002018-200225070-00007.