Details of the Drug

General Information of Drug (ID: DMYGITU)

Drug Name
CHDI-340246
Indication
Disease Entry ICD 11 Status REF
Huntington disease 8A01.10 Preclinical [1]
Drug Type
Small molecular drug
Cross-matching ID
TTD ID
DV8A1L

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kynurenine 3-hydroxylase (KMO) TTIY56R KMO_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
2 The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease. Exp Neurol. 2016 Aug;282:99-118.