Details of the Drug

General Information of Drug (ID: DMYPWHD)

• Drug Name: NLG919
• Synonyms: NLG919; 1402836-58-1; 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol; NLG 919; CHEMBL3629569; AK166956; 1-Cyclohexyl-2-(5H-imidazo-[5,1-a]isoindol-5-yl)ethanol; alpha-Cyclohexyl-5H-imidazo[5,1-a]isoindole-5-ethanol; 1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethan-1-ol; YTRRAUACYORZLX-UHFFFAOYSA-N; GTPL9019; SCHEMBL13280897; GDC0919; EX-A574; DTXSID20735206; MolPort-035-395-785; HMS3653M05; AOB87373; GDC 0919; NLG919(GDC-0919); 2588AH; RG6078; BDBM50126144; s7111; AKOS025287054; CS-3512; SB16495; ACN-028914; KS-0000062W

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 282.4
  Logarithm of the Partition Coefficient (xlogp); 3.5
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 2
• Chemical Identifiers:
  Formula: C18H22N2O
  IUPAC Name: 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
  Canonical SMILES: C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
  InChI: InChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
  InChIKey: YTRRAUACYORZLX-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 66558287
  CAS Number: 1402836-58-1
  TTD ID: D06MHZ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Immune checkpoint (ICH)	TTV8N19	NOUNIPROTAC	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039434)
• [2] Deal watch: Genentech dives deeper into the next wave of cancer immunotherapies. Nat Rev Drug Discov. 2014 Dec;13(12):879.