Details of the Drug

General Information of Drug (ID: DMZ2G69)

Drug Name

Navicixizumab

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Phase 1	[1]
Fallopian tube cancer	2C74	Phase 1	[2]
Metastatic colorectal cancer	2B91	Phase 1	[2]
Ovarian cancer	2C73	Phase 1	[1]
Peritoneal cavity cancer	2C51.Z	Phase 1	[2]
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Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Delta-like protein 4 (DLL4)	TTV23LH	DLL4_HUMAN	Not Available	[1]
Vascular endothelial growth factor A (VEGFA)	TTOHSBA	VEGFA_HUMAN	Not Available	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Colorectal cancer

ICD Disease Classification

2B91.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vascular endothelial growth factor A (VEGFA)	DTT	VEGFA	3.61E-01	0.15	0.47

Molecular Expression Atlas (MEA)

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)