Details of the Drug

General Information of Drug (ID: DMZCERW)

Drug Name	Pyrrole derivative 7
Synonyms	PMID27774822-Compound-Figure3compound229
Drug Type	Small molecular drug
Structure	3D Structure is Not Available
Structure	3D MOL	2D MOL
Cross-matching ID	TTD ID D0YJ4D

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Janus kinase 1 (JAK-1)	TT6DM01	JAK1_HUMAN	Inhibitor	[1]
Janus kinase 2 (JAK-2)	TTRMX3V	JAK2_HUMAN	Inhibitor	[1]
TYK2 tyrosine kinase (TYK2)	TTBYWP2	TYK2_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Janus kinase 2 (JAK-2)	DTT	JAK2	8.41E-07	0.36	1.03
Janus kinase 1 (JAK-1)	DTT	JAK1	6.35E-07	-0.28	-1.07

Molecular Expression Atlas (MEA)

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References

1	Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161.