Details of the Drug

General Information of Drug (ID: DMZCKDH)

• Drug Name: SUVN-504
• Synonyms: SUVN-503; SUVN-51005; 5-HT 6 antagonists (emesis), Suven; 5-HT 6 antagonists (obesity), Suven

Indication

Disease Entry	ICD 11	Status	REF
Vomiting	MD90	Investigative	[1]

• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 441.3
  Logarithm of the Partition Coefficient (xlogp); 4
  Rotatable Bond Count (rotbonds); 6
  Hydrogen Bond Donor Count (hbonddonor); 0
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C18H18BrFN2O3S
  IUPAC Name: 2-[5-bromo-1-(4-fluorophenyl)sulfonylindol-3-yl]oxy-N,N-dimethylethanamine
  Canonical SMILES: CN(C)CCOC1=CN(C2=C1C=C(C=C2)Br)S(=O)(=O)C3=CC=C(C=C3)F
  InChI: InChI=1S/C18H18BrFN2O3S/c1-21(2)9-10-25-18-12-22(17-8-3-13(19)11-16(17)18)26(23,24)15-6-4-14(20)5-7-15/h3-8,11-12H,9-10H2,1-2H3
  InChIKey: GTFCQLBBMSYCFM-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 11744001
  TTD ID: D0K8PH

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 6 receptor (HTR6)	TTJS8PY	5HT6R_HUMAN	Antagonist	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Vomiting
• ICD Disease Classification: MD90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 6 receptor (HTR6)	DTT	HTR6	1.23E-05	-0.12	-0.71

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11).