Details of the Drug

General Information of Drug (ID: DMZEECF)

Drug Name

Bradanicline

Synonyms

Bradanicline; 639489-84-2; TC-5619; Bradanicline (TC-5619); TC 5619; ATA-101; CHEMBL1258006; N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide; UM3821998K; 2-Benzofurancarboxamide, N-((2S,3R)-2-(3-pyridinylmethyl)-1-azabicyclo(2.2.2)oct-3-yl)-; 2-Benzofurancarboxamide, N-[(2S,3R)-2-(3-pyridinylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-; Bradanicline [USAN:INN]; UNII-UM3821998K; Bradanicline (USAN/INN); BRADANICLINE [INN]; BRADANICLINE [USAN]; BRADANICLINE [WHO-DD]; SCHEMBL372929; ATA101; GTPL3969; DTXSID40213778; OXKRFEWMSWPKKV-GHTZIAJQSA-N; EX-A7201; BDBM50393247; TC5619; compound 7a [PMID 23126648]; DB06090; HY-18060; MS-25725; CS-0007204; TC-5619-238; D10613; (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide; (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]octan-3-yl)benzofuran-2-carboxamide; N-[(2S,3R)-2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-2-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Chronic cough	MD12	Phase 2	[1]
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Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C22H23N3O2
Canonical SMILES: C1CN2CCC1C(C2CC3=CN=CC=C3)NC(=O)C4=CC5=CC=CC=C5O4
InChI: InChI=1S/C22H23N3O2/c26-22(20-13-17-5-1-2-6-19(17)27-20)24-21-16-7-10-25(11-8-16)18(21)12-15-4-3-9-23-14-15/h1-6,9,13-14,16,18,21H,7-8,10-12H2,(H,24,26)/t18-,21+/m0/s1
InChIKey: OXKRFEWMSWPKKV-GHTZIAJQSA-N

Cross-matching ID

PubChem CID: 25147644
TTD ID: D9PC0O

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-7 (CHRNA7)	TTLA931	ACHA7_HUMAN	Agonist	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT03622216) A Dose Escalation Study to Assess the Efficacy and Safety of Bradanicline in Subjects With Refractory Chronic Cough. U.S.National Institutes of Health.
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight