Details of the Drug | DrugMAP

General Information of Drug (ID: DMZI8GK)

Drug Name	Tricyclic compound 8
Synonyms	PMID27568917-Compound-Figure1(a)
Drug Type	Small molecular drug
Structure
Structure	3D MOL			2D MOL
#Ro5 Violations (Lipinski): 0	Molecular Weight (mw)			243.26
	Logarithm of the Partition Coefficient (xlogp)			1.3
	Rotatable Bond Count (rotbonds)			2
	Hydrogen Bond Donor Count (hbonddonor)			2
	Hydrogen Bond Acceptor Count (hbondacc)			2
Chemical Identifiers	Formula C13H13N3O2 IUPAC Name 5-(1H-indol-3-ylmethyl)-3-methylimidazolidine-2,4-dione Canonical SMILES CN1C(=O)C(NC1=O)CC2=CNC3=CC=CC=C32 InChI InChI=1S/C13H13N3O2/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18) InChIKey PANAMPMZPUJRLL-UHFFFAOYSA-N
Cross-matching ID	PubChem CID 194580 CAS Number 74311-00-5 TTD ID D0LF0B

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Receptor-interacting protein 1 (RIPK1)	TTAIQSN	RIPK1_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents.Expert Opin Ther Pat. 2016 Nov;26(11):1239-1256.